COX-2: promoting tolerance

Article Abstract:

Cyclooxygenase-2 (COX-2) appears to play a role in oral tolerance. Oral tolerance is the intestinal system's tolerance of foreign antigens in the food we eat and the bacteria that live in the gastrointestinal tract. COX-2 is involved in prostaglandin formation.

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Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen

Article Abstract:

Cyclooxygenase-2 (COX-2) is involved in immune tolerance to dietary and bacterial antigens in the gastrointestinal tract. Feeding mice a COX-2 inhibitor along with egg white lysozyme produced inflammatory changes in the intestinal mucosa.

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T cells are just dying to accept grafts

Article Abstract:

The death of T cells via apoptosis seems to make the immune system tolerate the antigen they recognized. This information could be used to prevent people from rejecting transplanted organs.

Prevention, Cell death, Graft rejection

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