Chemokine receptor CCR2b 64I polymorphism and its relation to CD4 T-cell counts and disease progression in a Danish cohort of HIV-infected individuals

Article Abstract:

Genetic variation in a chemokine receptor does not appear to significantly influence progression of HIV infection. HIV uses these receptors to gain access to cells it infects. Researchers in Denmark analyzed the genes of 215 people and found no difference in the CCR2b 64I gene region of the receptor between HIV infected and HIV-negative people. Among HIV-infected people, genetic variants of the chemokine receptor were not associated with immune system decline, CD4+ T-cell counts, or progression to AIDS. The 64I gene was not associated with long-term nonprogression of infection.

Physiological aspects, Cell receptors, CD4 lymphocytes

---

HIV-infected individuals with the CCR5-delta-32/CCR5 genotype have lower HIV RNA levels and higher CD4 cell counts in the early years of the infection than do patients with the wild type

Article Abstract:

Infection with a particular genetic form of HIV may lead to improved immune status during the early stages of disease. Patients with a mutant allele of the CCR5 gene have higher CD4 white blood cell levels and lower levels of HIV in the blood in early infection, but long-term benefits are small.

United States, Denmark, HIV (Viruses), HIV

---

Prognostic value of serum HIV-RNA levels at virologic steady state after seroconversion: relation to CD4 cell count and clinical course of primary infection

Article Abstract:

This study tried to determine if measurement of HIV-RNA provided useful prognostic value when done between six and 24 months after testing positive. The conclusion was that it is a very good indicator of disease progression.

Measurement, Prognosis, AIDS (Disease), Viremia, Viral load

Similar abstracts:

• Abstracts: CCR5 chemokine receptor variant in HIV-1 mother-to-child transmission and disease progression in children. Morbidity and mortality in European children vertically infected by HIV-1
• Abstracts: Zidovudine resistance, syncytium-inducing phenotype, and HIV diseases progression in a case-control study. Changes in plasma HIV RNA levels and CD4+ lymphocyte counts predict both response to antiretroviral therapy and therapeutic failure
• Abstracts: Risk factors and clinical presentation of acute primary HIV infection in India. Acute primary HIV infection
• Abstracts: Variability in physicians' reported ordering and perceived reassurance value of diagnostic tests in children with 'growing pains.'
• Abstracts: Immunization status and birth order. Immunization status as determined by patients' hand-held cards vs medical records

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.