ORP150 protects against hypoxia/ischemia-induced neuronal death

Article Abstract:

The role of astrocytes in the ischemic process is examined by analyzing polypeptides exposed to hypoxia. Results indicate a 150kD protein, ORP150, contributes to the viability of cells in the midst of oxygen deprivation.

Japan, Statistical Data Included, Research, Hypoxia, Anoxia, Neurons, Ischemia

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Human amyloid-(beta) synthesis and clearance rates as measured in cerebrospinal fluid in vivo

Article Abstract:

Accumulation of amyloid-(beta) in the brain and disease-causing mutations in amyloid precursor protein indicate dysregulation of production or clearance of A(beta) in Alzheimer disease. A method is prescribed to determine the production and clearance rates of proteins within the human central nervous system (CNS), which is estimated to be 7.6% ad 8.3% per hour, respectively, and this method may be used to search for novel biomarkers of the disease and to evaluate treatments.

United States, Health aspects, Care and treatment, Alzheimer's disease, Amyloid beta-protein, Cerebrospinal fluid

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