Coding potential of the X region of human T-cell leukemia/lymphotropic virus type II

Article Abstract:

Differences in proteins produced by certain gene sequences could explain the different diseases caused by human T-cell leukemia/lymphotropic viruses I and II (HTLV-I and HTLV-II). The viruses have similar genes and both can cause T cells to turn cancerous. However, HTLV-II has not been conclusively linked to any disease yet, unlike HTLV-I, which has been linked to adult T cell leukemia and a muscle disease. Analysis of the X region of the viral genes reveals that each virus produces different proteins. Research has shown that mutations in the X region can produce a less virulent virus.

Genetic code, HTLV-I (Virus)

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Tropism, coreceptor use, and phylogenetic analysis of both the V3 loop and the protease gene of three novel HIV-1 group O isolates

Article Abstract:

HIV uses the cell chemokine receptor 5 (CCR5) coreceptor to gain entry to human cells. Researchers studied the infectivity of three strains of HIV in white blood cells and human bone cancer cells. The protease gene of the three subgroups tested were closely related to the MVP-5180 strain of HIV. The tested viral strains did not appear to use cellular fusing, or syncytium formation, to infect the tested cells. All three strains infected peripheral blood mononuclear white blood cells and macrophages.

Infection, Physiological aspects, HIV (Viruses), HIV, Macrophages, Cell receptors

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Nucleotide sequence and restriction fragment-length polymorphism analysis of human T-cell lymphotropic virus type II (HTLV-II) in Southern Europe: evidence for the HTLV-IIa and HTLV-IIb subtypes

Article Abstract:

Restriction fragment-length polymorphism (RFLP) analysis of the genes of the human T-cell lymphotropic virus type II can determine which subtypes occur in different regions of the world. Researchers used RFLP to analyze the long terminal repeat (LTR) of HTLV-II in 29 samples from infected people living in Spain and Italy. Most were intravenous drug addicts. The analysis revealed both subtypes HTLV-IIa and HTLV-IIb. RFLP also revealed that each subtype has 4 to 6 different isolates.

Health aspects, DNA, Drug addicts, Drug abusers, Italians, Spaniards

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