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Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease

Article Abstract:

The comparison of a single 15-minute infusion of 5 mg of zoledronic acid with 60 days of oral risedronate (30 mg per day) for treating Paget's disease is presented. The results show that a single infusion of zoledronic acid produces more rapid, more complete, and more sustained responses in Paget's disease than does daily treatment with risedronate.

Author: Miller, Paul, Brown, Jacques P., Reid, Ian R., Hosking, David, Richardson, Peter, Connell, William Fraser, Mesenbrink, Peter, Zelenakas, Ken, Lyles, Kenneth, Saidi, Youssef, Guoqin Su, Pak, Judy, Luchi, Monica
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
New England States, Dosage and administration, New England, Risedronate, Osteitis deformans

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Zoledronic acid and clinical fractures and mortality after hip fracture

Article Abstract:

The effectiveness of zoledronic acid in prevention of new clinical fractures, to patients undergone hip fracture surgery is studied. Results concluded yearly infusion of zoledronic acid within 90 days of hip fracture surgery reduced risk of new clinical fractures raising survival rate.

Author: Pieper, Carl F., Lyles, Kenneth W., Jie Zhang, Adachi, Jonathan D., Orloff, John J., Boonen, Steven, Colon-Emeric, Cathleen S., Mesenbrink, Peter, Magaziner, Jay S., Mautalen, Carlos, Hyldstrup, Lars, Recknor, Chris, Nordsletten, Lars, Moore, Kathy A., Lavecchia, Catherine, Hodgson, Patricia K., Abrams, Ken, Horowitz, Zebulun, Eriksen, Erik Fink
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
Science & research, Care and treatment, Research, Patient outcomes, Prevention, Hip joint, Hip fractures

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Incidence of osteonecrosis of the jaw in women with posemenopausal osteoporosis in the Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly Pivotal Fracture Trial

Article Abstract:

A total of 7,714 women with postmenopausal osteoporosis were given placebo or intravenous zoledronic acid to determine the incidence of osteonecrosis of the jaw. The occurrence of osteonecrosis of the jaw in the sample was low, and healing of lesions can occur over three years.

Author: Eriksen, Erik F., Delmas, Pierre D., Reid, Ian R., Mesenbrink, Peter, Grbic, John T., Landesberg, Regina, Lin, Shou-Qing, Leung, Ping-Cheung, Casas, Noemi, Recknor, Christopher P., Hua, Ye
Publisher: American Dental Association Publishers Inc.
Publication Name: Journal of the American Dental Association
Subject: Health
ISSN: 0002-8177
Year: 2008
Goods & services distribution, Channels of Distribution, Health aspects, Usage, Bones, Distribution, Postmenopausal women, Company distribution practices, Osteonecrosis, Jaw diseases, Cover story

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Subjects list: Drug therapy, Zoledronic acid, United States, Clinical report
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