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Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes

Article Abstract:

A pacemaker that stimulates both the upper and lower part of the heart does not significantly reduce the risk of stroke or death from cardiovascular disease. These so-called physiologic pacemakers mimic the heart better than pacemakers that only stimulate the ventricles, which are the lower part of the heart. But in a study of 2,568 patients who were randomly assigned to receive a ventricular or a physiologic pacemaker, the rate of stroke or death from cardiovascular disease was similar in both groups. The only benefit was a slightly lower risk of atrial fibrillation in the patients who received a physiologic pacemaker.

Author: Talajic, Mario, Connolly, Stuart J., Kerr, Charles R., Gent, Michael, Roberts, Robin S., Yusuf, Salim, Gillis, Anne M., Sami, Magdi H., Tang, Anthony S.L., Klein, George J., Lau, Ching, Newman, David M.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2000
Methods, Cardiovascular diseases, Patient outcomes, Mortality, Stroke (Disease), Stroke, Cardiac pacing

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Pacemaker therapy for prevention of syncope in patients with recurrent severe vasovagal syncope: a randomized trial

Article Abstract:

A pacemaker will not necessarily prevent vasovagal syncope, according to a study of 100 patients. Syncope is the medical term for fainting, and vasovagal syncope means the fainting is caused by a nerve disorder. In this study, all 100 patients received a pacemaker, but 48 had a real pacemaker and 52 had a dummy pacemaker. The risk of recurring fainting was similar in both groups.

Author: Connolly, Stuart J., Gent, Michael, Roberts, Robin S., Sheldon, Robert, Thorpe, Kevin E., Ellenbogen, Kenneth A., Wilkoff, Bruce L., Morillo, Carlos
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
Electromedical and Electrotherapeutic Apparatus Manufacturing, Electromedical equipment, Pacemakers, Fainting

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Comparison of beta-Blockers, amiodarone plus beta-Blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators: The OPTIC Study: A randomized trial

Article Abstract:

A study was conducted to determine whether amiodarone plus beta-blocker or sotalol are better than beta-blocker alone for prevention of implantable cardioverter defibrillator (ICD) high-voltage shocks, which are painful. The conclusion revealed that amiodarone plus beta-blocker is effective for preventing the shocks and is more effective than sotalol but has an increased risk of drug-related adverse effects.

Author: Talajic, Mario, Dorian, Paul, Connolly, Stuart J., Gent, Michael, Roberts, Robin S., Thorpe, Kevin, Bailin, Steven, Fain, Eric S., Champagne, Jean, Coutu, Benoit, Gronefeld, Gerian C., Honhnloser, Stefan H.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2006
United States, Health aspects, Usage, Amiodarone, Electric shock, Electric shock injuries, Sotalol

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Subjects list: Evaluation, Prevention, Pacemaker, Artificial (Heart), Pacemakers
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