Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine

Article Abstract:

Vaccination of cynomolgus monkeys with a biologically active HIV-1 Tat protein has been found in a study to be safe and effective. It brings on a broad, specific immune response (both humoral and cellular), lowers infection with simian-human immunodeficiency virus (SHIV)-89.6P to undetectable levels and thereby prevents the CD4+ T-cell decrease. For HIV vaccine development, blocking virus entry seems less likely to succeed than controlling viral infection and blocking disease onset.

Italy, Netherlands, Sweden, Research, AIDS vaccines, Monkeys, Virus inactivation

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Therapeutic dendritic-cell vaccine for simian AIDS

Article Abstract:

Research demonstrates that inactivated whole virus-pulsed dendritic cell vaccines are effective in controlling the immunodeficiency virus caused diseases. Results indicate that simian immunodeficiency virus-infected rhesus monkeys develop a durable virus-specific cellular and humoral immunity upon vaccination with chemically inactivated and virus-pulsed dendritic cells.

China, France, Evaluation, Immunity, Immunity (Physiology), Viral vaccines, Dendritic cells

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Equivalent amplification of intrinsically variable nucleic acid sequences by multiple-primer-induced overlapping amplification assay: applications for universal detection and quantitation

Article Abstract:

The multiple-primer-induced overlapping amplification assay MUPROVAMA can detect many different genotypes of HIV and may be useful in measuring viral load. The assay and its effectiveness are described.

Measurement, Viremia, Viral load

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