Current concepts in AIDS pathogenesis: Insights from the SIV/Macaque model

Article Abstract:

The pathogenesis of AIDS is proved to be quite complex and dynamic with most of the critical events such as transmission, C[D4.sup.+] T cell destruction, occurring in tissues that are not easily accessible. While the disease can progress over years, many critical events take place within the first few weeks of infection even as most patients are unaware of their infection, thus the nonhuman primate model of AIDS is used widely to fill these gaps in understanding of AIDS pathogenesis.

Prevention, Disease transmission, Bacteria, Pathogenic, Pathogenic bacteria

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Chemokine antagonists as therapeutics: Focus on HIV-1

Article Abstract:

Human immunodeficiency virus type 1 (HIV-1) entry into target cells is multistep course that is binding to CD4 follow engagement of specific chemokine receptors (CCR5 or CXCR4) generating molecular rearrangements in the envelope transmembrane subunit that cause membrane fusion. Chemokine receptors antagonists that jam the interaction of the HIV-1 envelope with CCR5 or CXCR4 strongly inhibit HIV-1 in vitro.

Science & research, Health aspects, Research, Usage, Causes of, Membrane fusion, Chemokine receptors

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The influence of HLA genotype on AIDS

Article Abstract:

This review discusses the genetic effects of HLA class I and II loci on HIV disease and its progression to AIDS from the context of immune cell recognition. Research shows an association between the genetic determinants of HIV-1 disease and the HLA class I genes, implicating HLA genes in various aspects of HIV dsease and AIDS outcome.

Evaluation, Physiological aspects, Immunity, Immunity (Physiology), HLA histocompatibility antigens, HLA antigens, Epidemiology, Histocompatibility antigens, Epidemiologic methods

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