Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity

Article Abstract:

Dendritic cells (DCs) loaded with heart-specific self peptide induce CD4(super +1) T-cell-mediated myocarditis in nontransgenic mice. In vivo experimental evidence is provided to support that the combined action of innate and adaptive immunity on dilated cardiomyopathy (DCs) triggers autoimmune heart disease, relapses and cardiomyopathy.

Autoimmune diseases, Cardiomyopathy, Dilated, Congestive cardiomyopathy, Dendritic cells

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L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomypathy

Article Abstract:

Iron-overload cardiomypathy is considered to be the most significant factor in patient survival. Results indicate that cardiac LVDCCs are important transporters of iron into cardiomyocytes under iron-overload conditions and are representing a new therapeutic target to reduce the cardiovascular burden from iron overload.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Iron & Other Tonics, Care and treatment, Usage, Iron in the body, Iron (Nutrient), Cardiomyopathy, Myocardial diseases

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The tyrosine kinase p56(super lck) is essential in coxsackievirus B3-mediated heart disease

Article Abstract:

The sarcoma family kinase p56(super lck) is involved in the replication of coxsackievirus B3. Mice who lacked the gene for this enzyme were completely protected from coxsckievirus B3-induced heart disease.

Health aspects, Viruses, Protein kinases, Coxsackieviruses

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