Development and characterization of a clinically useful animal model of epithelial ovarian cancer in the Fischer 344 rat

Article Abstract:

Rats injected with NuTu-19 tumor cells appear to be an effective model for studying ovarian cancer. Fischer 344 rats were injected with NuTu-19 cells and analyzed for survival time and tumor growth patterns. Additional rats were analyzed for their ability to become immune to the tumor cells. Tumor growth patterns were similar to ovarian cancer growth patterns. Average life span after injection with 1 million cells was 49 days. Injections with inactive NuTu-19 cells did not give them immunity to subsequent injections with active cells.

Models, Diseases, Ovarian cancer, Rats as laboratory animals, Laboratory rats

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Racial differences in the overexpression of epidermal growth factor type II receptor (HER2/neu): A major prognostic indicator in uterine serous papillary cancer

Article Abstract:

The association of overexpression of HER2/neu oncogene with poor outcome in uterine serous papillary endometrial cancer is examined and the contribution of racial difference in the frequency of HER2/neu overexpression to the disparity in endometrial cancer survival is determined. It is found that the overexpression of HER2/neu in uterine serous papillary endometrial cancer is associated with poor outcome, occurring frequently in black women and also possibly contributing to racial disparity in survival.

Italy, Health aspects, Care and treatment, Women, Endometrial cancer, Epidermal growth factor, Epidermal growth factors

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The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer

Article Abstract:

Tumor-associated differentially expressed gene-14 (TADG-14), a novel transmembrane serine protease, is reported to be highly overexpressed in ovarian carcinomas. A study conducted to investigate the frequency of expression of the TADG-14 gene in human cervical tumors suggests that this protease plays an important role in invasion and metastasis.

Research and Development in the Physical, Engineering, and Life Sciences, Science & research, Research and Testing Services, Gynecological R&D, Research, Evaluation, Gene expression, Tumor antigens, Gynecological research, Tumour antigens

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