Does excess weight cause osteoarthritis and, if so, why?

Article Abstract:

Excess weight likely predisposes persons to the development of osteoarthritis. Studies consistently show that overweight persons are much more likely to develop knee osteoarthritis and somewhat more likely to develop hip osteoarthritis. This suggests that weight bearing plays a role. However, they are also at higher risk for hand osteoarthritis, and women past menopause are more likely to develop osteoarthritis, which suggests that systemic or other factors play a role. In further support of overweight causing osteoarthritis, one study concluded that weight loss prevented development of osteoarthritis and another that weight loss relieved osteoarthritic symptoms in affected persons.

Obesity

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Nutrition: risk factors for osteoarthritis

Article Abstract:

Preliminary studies suggest that vitamin C, D, and E supplements may slow the progression of osteoarthritis (OA). Patients with OA taking these vitamin supplements have had significantly less joint pain and joint X-rays have shown less joint damage over time. These positive effects may occur because each vitamin is important in bone or cartilage metabolism. Vitamins C and E may also be acting as antioxidants and protecting joints from injury. However, none of these vitamins has been proven effective in preventing OA from starting. OA typically progresses more rapidly among overweight patients but the role of diet is unclear.

Vitamins, Antioxidants, Antioxidants (Nutrients)

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Sex hormones and the risk of osteoarthritis in women: epidemiological evidence

Article Abstract:

Female hormones likely play a role in the onset of osteoarthritis. Studies consistently show a rapid rise in the occurrence of osteoarthritis in women after menopause, especially in the hand joints. A connection with sex hormone levels is plausible in that sex hormones are known to influence cartilage metabolism. However, there appear to be no factors that identify women at greater risk. No associations have been found between age at onset of menstruation or age at menopause, or with hysterectomy once other factors are taken into account, although having more children may have a small protective effect.

Women, Physiological aspects, Women's health, Hormones, Sex, Sex hormones

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