Does previous Chlamydia trachomatis infection influence the pregnancy rate of in vitro fertilization and embryo replacement?

Article Abstract:

Salpingitis, or inflammation of the uterine tube (through which a fertilized egg or ovum mast pass prior to uterine implantation), can cause tissue fibrosis and lead to infertility due to damage within the fallopian tubes. Fallopian tube damage, due to all causes, is the single most common diagnosis for female infertility. Chlamydia trachomatis is known to be a major cause of salpingitis. Antibodies to chlamydia, which serve as an immunological record of past chlamydia infections, are strongly associated with infertility due to tubal factors. To determine if past chlamydia infection had an influence on a woman's chances for successful implantation with an in vitro fertilized embryo, antibodies were measured in 121 patients who underwent in vitro fertilization; 90 women were found to have a significant antibody titer. Although the large percentage of women with chlamydial antibodies was not surprising in a population with tubal factor infertility, the 32 women who achieved pregnancy had the same percentage of chlamydial antibodies as those who did not become pregnant. Although chlamydial antibodies are associated with fallopian tube-related infertility, they do not serve as a useful indicator for the chances of success with in vitro fertilization. (Consumer Summary produced by Reliance Medical Information, Inc.)

Research, Infection, Prognosis, Uterus, Fertilization in vitro, Human, Human fertilization in vitro

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Postabortal infectious morbidity after antibiotic treatment of Chlamydia-positive patients

Article Abstract:

The cases of 69 Chlamydia-positive women who had undergone abortions were studied to determine the possibility of reducing the risk of postabortal infectious morbidity by preoperative screening for Chlamydia. The infection rate of the 69 women was compared with the infection rate of 138 Chlamydia-negative women. Five of the 69 Chlamydia-positive women developed inflammation of the lining of the uterus (endometritis) during the first month after abortion, while none of the 138 Chlamydia-negative women developed endometritis. The slight differences are not statistically significant, but are indicative of the effectiveness of preoperative screening for Chlamydia before a legal abortion. Antibiotic treatment before or at the time of abortion can also reduce the risk of chlamydia infection later.

Antibiotics, Complications and side effects, Drug therapy, Chlamydia infections

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The influence of sexual and social factors on the risk of Chlamydia trachomatis infections: a population-based serologic study

Article Abstract:

The number of young women whose blood tests positive for Chlamydia trachomatis may be higher than the number who are actually infected with the disease. C. trachomatis is the most common bacterial sexually transmitted disease (STD). Researchers in Sweden analyzed the risk factors of young women ages 19, 21, 23, and 25, for C. trachomatis. The infection rate was a low 3% but 25% of the women tested positive for C. trachomatis, meaning that they had been infected at one time and had developed antibodies. Young age at first sexual intercourse, high number of sexual partners, and histories of pelvic inflammatory disease or abortion were found to be risk factors for C. trachomatis. Method of contraception, including oral, barrier, or other, was not found to influence risk.

Sexual behavior, Risk factors, Young women

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