Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype

Article Abstract:

Certain members of the CAMPATH-1 family of antibodies may possess a strong in vivo lympholytic ability and may be a useful and powerful new tool in the treatment of malignancies of the lymphoid tissues. When various mixtures from the CAMPATH family were used to treat patients with a form of chronic B-cell lymphocytic leukemia, the antibodies caused a decrease in the number of lymphocytes in the peripheral blood, without affecting marrow cells. Although treatment with immunoglobulin G2b (IgG2b) also depleted lymphocytes in the circulation, it had a sustained effect on the bone marrow. IgG2b was also able to improve the extreme enlargement of spleen and liver which accompanied the disease.

Health aspects, Drug therapy, Immunoglobulins, Cell differentiation, Leukemia

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Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophils

Article Abstract:

Monoclonal antibodies (artificially synthesized, exceptionally pure and specific proteins developed to respond to particular antigens) were produced by cells growing in tissue culture which were targeted against the b558 cytochrome, a pigment molecule, associated with an important respiratory enzyme system located on the membrane of some white blood cells. The gene for this molecule is most probably located on an autosomal chromosome (a non-sex chromosome), and on the X chromosome. The results show that the expression of this cytochrome can be affected when either of the two controlling genes are involved.

Neutrophils, Cytochromes, Chronic granulomatous disease

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Characterization of the blood group Kell (K1) antigen with a human monoclonal antibody

Article Abstract:

The Kell antibody is one that is directed against the Kell blood group (similar to the A and B blood groups). In this experiment anti-Kell antibodies were produced by a human B lymphocyte, a white blood cell, growing in tissue culture that had been infected with the Epstein-Barr virus. Individual cells were induced to produced clones, or cells carrying the same genetic information, which allowed them to produce the monoclonal antibody against the Kell blood group. The antibodies were used to study the nature of the Kell blood group.

Research, Blood groups, ABO blood-group system, Blood group antigens

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