Effects of HIV-1 Tat on expression of HLA class I molecules

Article Abstract:

The HIV-1 Tat protein may not necessarily decrease levels of major histocompatibility complex (MHC) class I proteins. MHC class I proteins are responsible for the recognition and destruction of virally infected cells by the immune system's cytotoxic T lymphocytes. Researchers examined the effect of the presence of Tat proteins in a cell line derived from human immune cells. They observed no changes in MHC class I gene activity or in the presence and processing of HLA-A2 MHC class I proteins. Tat protein, a known gene activator, is crucial in the HIV-1 life cycle and has been reported to have immunosuppressive effects. Decrease in MHC class I gene activity caused by the Tat protein has been proposed to result in the immune dysfunction characteristic of AIDS.

HIV infection, HIV infections, Genetic regulation, Genetic transcription, Transcription (Genetics), Major histocompatibility complex, Immunosuppression

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Dendritic cells transduced with HIV Nef express normal levels of HLA-A and HLA-\b class I molecules

Article Abstract:

The HIV Nef protein does not change HLA class I molecules on the surface of dendritic cells as it does when it infects T cells. Dendritic cells are produced by the immune system.

Infection, HLA histocompatibility antigens, HLA antigens, Antigen presenting cells

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Anti-V3 and anti-IgG antibodies of healthy individuals share complimentarity structures

Article Abstract:

The authors note that certain antibodies which interreact with HIV are also present in people who are HIV-negative. They describe their analyses of structure and type.

Immunoglobulin G

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