Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs
Article Abstract:
Drugs in the category of corticosteroids have been associated with an increased risk of ulcers, but not all studies have shown this association. Drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs) have also been associated with the development of peptic ulcer disease, with very convincing evidence. Over 1,400 patients were studied to determine whether the corticosteroids they were taking provoked the development of ulcer disease, or if the other drugs those patients might be receiving might be responsible. Oral corticosteroid use was found to be associated with a doubling of the risk for ulcer disease in this group of elderly Medicaid patients, but further analysis of the data revealed that the risk remained high only for those steroid users who were also taking NSAIDs. Those who used both types of drugs had a risk nearly 15 times that of the general population. These data must be interpreted somewhat cautiously, however, in that those patients who take both steroids and NSAIDs are likely to have more serious underlying disease and to be in poorer health generally. Nevertheless, those patients who are receiving both corticosteroids and NSAIDs must be monitored very carefully for the development of peptic ulcer disease, and might be good candidates for drugs designed to prevent ulcers. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1991
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A randomized trial of a consultation service to reduce falls in nursing homes
Article Abstract:
A comprehensive program to identify and correct hazards in nursing homes that could cause falls may reduce the rate of falls among the elderly residents. Researchers developed an intervention that was applied to one nursing home in each of seven pairs of nursing homes, while the other facility served as a control group. The intervention consisted of a complete evaluation of hazards such as psychotropic drug use, improperly designed wheelchairs, improper techniques for transferring residents from bed to chair and room design. When these were corrected, the rate of falls fell 20% and there was a slight trend toward a lower injury rate.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1997
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