Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon

Article Abstract:

Hepatitis B virus production and its enhanced inhibition by using asialoglycoprotein receptor-directed interferon (IFN) are discussed. Most chronic carriers of hepatitis B virus do not respond to IFN treatment, perhaps because of low expression of IFN receptor in their livers. Modified IFN showed greater inhibition of HBV production in ASGP receptor-positive human liver cells transfected with a replication-competent HBV construct than did conventional IFNs.

Health aspects, Usage, Glycoproteins, Cytochemistry, Hepatitis B, Liver cells, Hepatocytes, Interferon

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SADS: a new component of Fas-DISC is the accelerator for cell death signaling and is downregulated in patients with colon carcinoma

Article Abstract:

Research presented concerns the regulation of apoptosis or cell death, focusing on the discovery of a protein, small accelerator for death signaling (SADS), that may accelerate Fas-mediated death. Topics addressed include tumorgenesis, death-induced signaling complex, and the downregulation of SADS in patients with colon cancer.

Japan, Statistical Data Included, Colorectal cancer, Proteins, Cellular control mechanisms, Cell regulation, Cell receptors

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A SADS defect in tumor cells provides optimism

Article Abstract:

Research presented concerns the regulation of apoptosis or cell death, focusing on the discovery of a protein, small accelerator for death signaling (SADS), that may accelerate Fas-mediated death. Topics addressed include tumorgenesis, death-induced signaling complex, and the downregulation of SADS.

Gene expression, Tumors

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