Fetal and maternal hemodynamic and metabolic effects of maternal nitroglycerin infusions in sheep

Article Abstract:

Nitroglycerin used to prevent preterm labor may not adversely affect the fetus. Researchers analyzed the effects of gradually increasing doses of infused nitroglycerin in pregnant sheep over a two-hour period. The ewe's average arterial pressure decreased significantly while the heart rate increased. Nitroglycerin infusion did not affect the fetus adversely even though blood flow to nonvital organs was somewhat reduced. Nitroglycerin might be used to subdue uterine contractions in pregnant women in preterm labor.

Hemodynamics

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Effects of nitroglycerin and indomethacin on fetal-maternal circulation and on fetal cerebral blood flow and metabolism in sheep

Article Abstract:

Nitroglycerin given during premature labor does not appear to adversely affect the fetus or the mother according to a study of pregnant sheep. Nitroglycerin is converted by the body into nitric oxide, which relaxes the uterus and stops premature uterine contractions. Indomethacin also had no adverse effects on the fetal lambs.

Cerebral circulation, Blood circulation, Indomethacin

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Nitroglycerin application during cesarean delivery: plasma levels, fetal/maternal ratio of nitroglycerin, and effects in newborns

Article Abstract:

Nitroglycerin given to pregnant women in labor to relax the uterus should not have any adverse effect on the baby. Although nitroglycerin can cross the placenta, a study of 62 pregnant women showed that levels of the drug in the umbilical cord were much lower than in the mother's blood.

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