The maternal-fetal transfer of bisheteropiperazine (U-87201-E) in the ex vivo human placenta

Article Abstract:

Bisheteroypiperazine, a new HIV antiviral medication, passed readily across the placenta in laboratory experiments. Segments of fresh placentas had catheters placed on both the maternal and fetal sides. Bisheteroypiperazine infused into the maternal side passed readily to the fetal side. The mechanism appears to be simple diffusion and does not appear to involve a placental transport mechanism. With the increasing resistance of HIV to zidovudine, new medications must be found to protect the fetuses of HIV-infected mothers. Whether bisheteroypiperazine could damage the forming fetus is as yet unknown but should be studied.

Maternal-fetal exchange, Fetus, Antiviral agents, Perfusion (Physiology)

---

Failure of decidual arteriolar remodeling in the CBA/J X DBA/2 murine model of recurrent pregnancy loss is linked to increased expression of tissue inhibitor of metalloproteinase 2 (TIMP-2)

Article Abstract:

A study is carried out to elucidate any differences in structural remodeling in normal murine pregnancies versus those differences that resulted from the crossing of CBA/J female mice by DBA/2 male mice, a combination that is known to exhibit recurrent resorption/pregnancy loss. The expansive vascular remodeling of decidual vessels that is characteristic of normal murine pregnancy is attenuated significantly in the CBA/J X DBA/2 mating combination, which is known for its tendency to recurrent fetal resorption.

United States, Health aspects, Causes of, Metalloproteins, Uterus, Fetal death

---

Similar abstracts:

• Abstracts: Neonatal hepatitis and extrahepatic biliary atresia associated with cytomegalovirus in twins. Asymptomatic congenital cytomegalovirus infection: audiologic, neuroradiologic, and neurodevelopmental abnormalities during the first year
• Abstracts: Cardiomyopathy associated with the smoking of crystal methamphetamine. Disposition and pharmacodynamics of methamphetamine in pregnant sheep
• Abstracts: Acute allergic reaction associated with reprocessed hemodialyzers - United States, 1989-1990. Allergic skin disorders and mastocytosis
• Abstracts: Protein losing enteropathy associated with collagen diseases. Arthritis in mice induced by a single immunisation with collagen
• Abstracts: Membranous nephropathy related to hepatitis B virus in adults. Membranous nephropathy - still a treatment dilemma

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.