Fluoroquinolone treatment failure in gonorrhea: emergence of a Neisseria gonorrhoeae strain with enhanced resistance to fluoroquinolones
Article Abstract:
Use of fluoroquinolone to treat gonorrhea may be the cause of a growing number of fluoroquinolone-resistant strains of gonorrhea. Researchers analyzed fluoroquinolone-resistance in one male patient with gonococcal urethritis due to Neisseria gonorrhoeae by testing the disease isolates from the urethra before and after treatment with multiple doses of ofloxacin. The after-treatment isolate proved that ofloxacin failed to eradicate the gonorrhea in this patient. The after-treatment isolate showed an increased resistance to fluoroquinolones and a decreased uptake of ofloxacin. Posttreatment antibiotic susceptibility of gonococcal isolates should be determined to discourage drug-resistant strains of gonorrhea.
Publication Name: Sexually Transmitted Diseases
Subject: Health
ISSN: 0148-5717
Year: 1997
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Antimicrobial susceptibilities of strains of Neisseria gonorrhoeae in Bangkok, Thailand: 1994-1995
Article Abstract:
It appears that a significant percentage of gonorrhea infections in Thailand may be resistant to many conventional therapies. Resistance to tetracycline, penicillin G, and other treatments were determined among 101 patients with gonorrhea in Bangkok, Thailand between 1994 and 1995. Eighty-nine percent of the gonorrhea samples failed to respond to tetracycline or penicillin. Further tests determined that the cellular source of the tetracycline and penicillin resistance was plasmids in 33.7% of the samples and chromosomes in 51.5% of the samples.
Publication Name: Sexually Transmitted Diseases
Subject: Health
ISSN: 0148-5717
Year: 1997
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Infection with HIV-1 subtypes B and E in injecting drug users screened for enrollment into a prospective cohort in Bangkok, Thailand
Article Abstract:
Among injecting drug users (IDUs) in Bangkok, Thailand, the majority of people who are HIV positive are primarily subtype B'. In studying 1,674 IDUs, 29.3% were found to be seropositive, and of them, 65% were HIV-1 subtype B' and 35% subtype E. the subtype E infection was primarily found among the younger people and did not seem to result from sexual behavior. Most of the infection, of both types, comes from needle transmission.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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