Heparin-induced thrombocytopenia and thrombosis

Article Abstract:

Research has shed light on the paradoxical association between heparin-induced thrombocytopenia and the development of blood clots in surgical patients who receive heparin. Heparin-induced thrombocytopenia is a drop in the number of blood cells called platelets that can occur when the body forms antibodies against heparin. However, several 1994 studies revealed that the antibodies are not against heparin, but against heparin bound to platelet factor 4, a chemical found in platelets. These antibodies could bind to chemicals similar to heparin on the inside of blood vessels and damage them. This could lead to the formation of blood clots. A 1995 study found that none of the 330 surgical patients who received low-molecular-weight heparin developed thrombocytopenia. They were also less likely to develop antibodies against heparin than patients who received standard heparin.

Editorial, Causes of, Physiological aspects, Thrombocytopenia, Thrombosis, Heparin

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Drug-induced immune thrombocytopenia

Article Abstract:

The conditions in which the exposure to a drug has led to the destruction of circulating platelets, often accompanied by bleeding symptoms, are examined. Patients with drug-induced thrombocytopenia should avoid permanently the medication that might cause this condition.

Drugs, Diagnosis, Risk factors, Thrombocytopenic purpura, Adverse drug reactions

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