Glucosamine and Chondroitin for Treatment of Osteoarthritis: A Systematic Quality Assessment and Meta-analysis
Article Abstract:
Glucosamine and chondroitin preparations may be beneficial in treating osteoarthritis. Researchers used meta-analysis to evaluate 15 studies of glucosamine and chondroitin in treating osteoarthritis. Meta-analysis is used to combine the results of many small studies into one overall result. Many of the studies were not well-designed and were either supported or performed by the manufacturer of the product. When only high-quality or large trials were considered, the compounds were less effective than the overall score indicated. Nevertheless, most of the studies showed some benefit from these compounds.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2000
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Glucosamine and Chondroitin for Treating Symptoms of Osteoarthritis: Evidence Is Widely Touted but Incomplete
Article Abstract:
More research is needed to determine whether glucosamine sulfate and chondroitin sulfate are beneficial in the treatment of osteoarthritis. Their exact mechanism is not known, but both have been effective in animal models of osteoarthritis. A study published in 2000 evaluated several studies and found that most of the studies were not well-done. Thus, the benefits of these compounds may have been exaggerated in the past. The US National Institutes of Health will fund a large study to determine their effectiveness.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2000
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Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis
Article Abstract:
More research is needed to determine whether injections of hyaluronic acid into the knee is an effective treatment for osteoarthritis, according to researchers who analyzed 22 clinical trials. High-molecular-weight hyaluronic acid may be more effective than low-molecular-weight hyaluronic acid. Hyaluronic acid is a natural substance in joints that may be deficient in people with osteoarthritis.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
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