Granuloma inguinale (Donovanosis) in women: an analysis of 61 cases from Durban, South Africa

Article Abstract:

Granuloma inguinale (GI), which causes genital ulcerations and is thought to be a sexually transmitted disease, can be difficult to diagnose since its symptoms can mimic those of other diseases. Of 61 women patients at a South African gynecological and antenatal clinic who were eventually diagnosed with GI, many were initially thought to suffer from a variety of diseases including cervical cancer and pelvic inflammatory disease. Genital ulceration and bleeding were the most common symptoms of GI. Symptoms differed for non-pregnant and pregnant women. Non-pregnant women were more likely to have lesions in more than one site, though pregnant women were more likely to have incidences genital ulceration. Erythromycin was the most popular treatment for GI, but other antimicrobials were also used successfully. Treatment generally lasted from two weeks to three months depending on the size of the lesions.

Sexually transmitted diseases, Care and treatment, Diagnosis, Sexually transmitted disease diagnosis

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Antibiotic susceptibility patterns and plasmid profiles of penicillinase-producing Neisseria gonorrhoeae strains in Durban, South Africa, 1990-1993

Article Abstract:

Increases of penicillin-resistant gonorrhea in South Africa may point out the need for continued surveillance of antimicrobial-resistant gonorrhea strains. Researchers analyzed 321 gonorrhea strains from adult men with acute inflammation of the urethra in Durban, South Africa. The rate of penicillinase-producing Neisseria gonorrhoeae (PPNG) strains, which are resistant to penicillin, increased from 16.4% to 19% from 1990 to 1993. Gonorrhea strains were resistant to penicillin but were treatable, in varying degrees, to ciprofloxacin, ceftriaxone, and tetracycline. Asian gonorrhea strains were more prevalent than West African strains.

Demographic aspects, Drug resistance in microorganisms, Microbial drug resistance, Neisseria gonorrhoeae

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Clinico-epidemiologic features of granuloma inguinale in the era of acquired immune deficiency syndrome

Article Abstract:

HIV-infected patients may have a more serious case of granuloma inguinale (GI), which could increase their risk of transmitting HIV. GI is a sexually transmitted disease in India that causes ulcers on the genitals. Researchers examined 21 HIV-positive GI patients and 29 HIV-negative GI patients. All patients were treated with erythromycin. GI ulcers in HIV-positive patients took longer to heal than in HIV-negative patients and also produced greater tissue damage. This could facilitate the transmission of HIV.

Evaluation, Physiological aspects, Diseases, HIV patients, Wound healing

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