HIV-1 dynamics in children

Article Abstract:

The progression of HIV infection appears to be different in children. Many researchers have discovered that HIV infection in children progresses more rapidly compared to adults. Researchers measured blood levels of HIV in eight children who began highly active antiretroviral therapy (HAART). Viral levels dropped rapidly during the first one to two weeks but then dropped more slowly thereafter. Although the declines during the first one to two weeks were similar to those seen in adults, the decline thereafter was much slower than in adults. It took the children longer than adults to reach an undetectable virus level.

Measurement, Development and progression, HIV (Viruses), HIV, HIV infection in children, Pediatric HIV infections, Viremia, Viral load

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The quest study, from a clinician with immunological inclination

Article Abstract:

The results from the Quest study were presented and this was designed to evaluate therapeutic vaccines administered in addition to highly active antiretroviral therapy initiated during primary HIV infection. This study population is being followed for a longer term assessment of the immunization strategy in terms of laboratory and clinical parameters such as CD4 counts, HIV viremia, time to restart highly active antiretroviral therapy (HAART), and advent of opportunistic infections.

Research and Development in the Physical, Engineering, and Life Sciences, Immunology

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Density-dependent decay in HIV-1 dynamics

Article Abstract:

The decay of HIV-1 infected cell populations after treatment with antiretroviral therapy is measured using simple exponential decay models. It is concluded that long-term viral dynamics of HIV infection based on simple exponential decay models should be carefully re-evaluated.

T cells

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