Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis

Article Abstract:

Low-dose diuretics should be the first drug used to treat all patients with high blood pressure, according to a review of 42 clinical trials covering 192,478 patients. Low-dose diuretics were more effective in reducing the risk of coronary heart disease, heart attack, stroke, and congestive heart failure than other antihypertensive drugs such as calcium channel blockers, beta blockers, ACE inhibitors, and alpha blockers.

Blood Pressure Preparations, Renal Diuretic Preparations, Evaluation, Cooking, Hypertension, Drug therapy, Antihypertensive drugs, Antihypertensive agents, Diuretics, Cookery for hypertensives

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Potential for conflict of interest in the evaluation of suspected adverse drug reactions: Use of cerivastatin and risk of rhabdomyolsis

Article Abstract:

The association between the use of cerivastatin sodium and the risk of rhabdomyolysis is reviewed in order to illustrate the operation and limitations of the current US post marketing safety-surveillance system. The findings suggest that compared with atrovastatin calcium, cerivastatin monotherapy substantially increased the risk of rhabdomyolysis.

United States, Drugs, Adverse drug reactions, Rhabdomyolysis

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Esterified estrogens and conjugated equine estrogens and risk of venous thrombosis

Article Abstract:

The risk of venous thrombosis among esterified estrogen users, conjugated equine estrogen users and nonusers are compared. The results revealed that conjugated equine estrogen associated with venous thrombotic risk needs to be replicated and may have implications for the choice of hormones in perimenopausal and postmenopausal women.

Estrogen & Progestogen Preps, Health aspects, Thrombophlebitis, Postmenopausal women, Estrogen, Estrogens

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