Heat-labile, complement-like factor(s) of animal sera prevent(s) HIV-1 infectivity in vitro

Article Abstract:

The complement system comprises a group of molecules in the blood serum that cause the inactivation of viruses, preventing them from causing infection. Complement also causes the destruction, or lysis, of cells that are infected with viruses and other foreign agents. In the body, the human immunodeficiency virus type-1 (HIV-1) is not inactivated by complement. Blood obtained from many types of animals was tested for its ability to inactivate HIV-1. Sera from humans and chimpanzees did not inactivate HIV-1. However, serum from other mammals, especially rodents and cats, was able to inactivate HIV-1 that was not bound to or present inside cells. The activity in the sera appears to be complement, as it has similar properties, such as the ability to be destroyed by heat and requiring calcium for activation. Further study of the mechanism of destruction of the virus and why this activity is not seen in humans may lead to further understanding of HIV infection. If the process can be understood, it may be developed as part of a treatment in controlling AIDS. (Consumer Summary produced by Reliance Medical Information, Inc.)

Physiological aspects, Complement (Immunology)

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Male circumcision in Siaya and Bondo districts, Kenya: Prospective cohort study to assess behavioral disinhibition following circumcision

Article Abstract:

A prospective cohort study is used to study the efficacy of male circumcision as a HIV prevention measure and also its effect on sexual behaviors of men in public health care setting. The analysis has shown that any protective effect of male circumcision on HIV acquisition is unlikely to be offset by an adverse behavioral impact.

Kenya, Sexual behavior, Analysis, Men, Circumcision, Clinical report

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Allo-immunization elicits CD8+ T cell-derived chemokines, HIV suppressor factors and resistance to HIV infection in women

Article Abstract:

Allo-immunization against HIV may be an effective strategy for preventing HIV infection. A group of women who were allo-immunized against their partner's blood cells to prevent miscarriage also became more resistant to HIV infection.

Research, AIDS vaccines

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