Heterogeneity of spindle cells in Kaposi's sarcoma: comparison of cells in lesions and in culture

Article Abstract:

The spindle-shaped cells in lesions of different types of Kaposi's sarcoma (KS) appear to originate from various cell types and probably grow in response to cofactors and cytokines. Researchers analyzed the antigens and DNA from spindle cells from three types of Kaposi's sarcoma: sporadic "classic" KS (SKS), endemic KS (EKS), and epidemic AIDS-related KS (AKS). The appearance, distribution, and expression of antigens of spindle cells in the different KS lesions were similar. Cells were reactive for a variety of antigens including EN4, CD34, CD45, vimentin, and expressed TE7 and collagen type antigens. These markers indicate that KS spindle cells have antigens that resemble those expressed by various cell types including fibroendothelial, fibromyocytic, and smooth muscle. The diversity of markers suggests that spindle cells do not grow by proliferation of a single tumor cell type, but in response to growth agents.

Cytopathology

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Consideration of host-viral interactions in the pathogenesis of Kaposi's sarcoma

Article Abstract:

The author points to the identification of human herpes virus type 8 (HHV-8) as the most likely cause of Kaposi's sarcoma (KS), that certain physiological phenomena indicate that infection with HHV-8 is necessary to the development of KS. Based on this and other facts, she then presents a theoretical model of the development of KS and the mechanisms involved in the process.

Statistical Data Included, Physiological aspects, Development and progression, Human herpesvirus 8

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