Hexokinase II activity and messenger ribonucleic acid abundance in adipose tissue and skeletal muscle during pregnancy and lactation in rats
Article Abstract:
Insulin resistance found in fat tissue during late pregnancy may result from reduced expression of the hexokinase II gene. Hexokinase is a catalyst for the breakdown of glucose. Researchers obtained abdominal fat tissue and quadriceps muscle from nonpregnant, pregnant, and lactating rats to measure hexokinase II gene expression in these tissues. The amount and activity of hexokinase II in fat tissue from pregnant rats was lower than in fat from nonpregnant rats. Hexokinase II levels and activity remained the same in quadriceps muscle regardless of pregnancy or lactation.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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Identification of gestationally regulated genes in rat myometrium by use of messenger ribonucleic acid differential display
Article Abstract:
A simple technique used to evaluate messenger ribonucleic acid (mRNA) patterns called polymerase-chain reaction appears to provide useful information about changing gene expression in the uterine lining during pregnancy. Uterine lining samples taken from 30 pregnant rats on days 12, 16, 20, 21, 22 of pregnancy and one day after delivery were analyzed using polymerase-chain reaction. More than 500 mRNA sequences were identified. Some sequences were expressed more frequently and some less frequently as the pregnancy advanced.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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Expression of adenosine triphosphate-sensitive potassium channel subunits in female rat reproductive tissues: overlapping distribution of messenger ribonucleic acid for weak inwardly rectifying potassium channel subunit 6.1 and sulfonylurea-binding regulatory subunit 2
Article Abstract:
The potassium channel in uterine tissue consists of the weak inwardly rectifying potassium channel subunit 6.1 and the sulfonylurea-binding regulatory subunit 2. Potassium channels are channels in cell membranes that permit potassium ions to enter the cell. Activation of potassium channels inhibits uterine contractions. Therefore, researchers hope to develop drugs that can activate potassium channels and thereby stop premature labor.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1999
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