Human embryonic stem cells express an immunogenic nonhuman sialic acid

Article Abstract:

Human embryonic stem cells (HESC) are typically cultured with animal-derived 'serum-replacements' on mouse feeder layers, both of which are sources of the nonhuman sialic acid Neu5Gc, against which many humans have circulating antibodies. The HESC and derived embryoid bodies metabolically incorporate substantial amounts of Neu5Gc under standard conditions.

United States, Immunogenetics

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Logistical hurdles slow California's lofty stem cell scheme

Article Abstract:

California's new Institute for Regenerative Medicine is forging ahead with schemes for human embryonic stem cell research by early May 2005. An array of logistical hurdles remain which includes the selection of the 15-member working group of stem cell scientists that will recommend criteria for successful grants and review the applications that come in.

Management dynamics, California, Management, Company business management, California. Institute for Regenerative Medicine

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Derivation of engraftable skeletal myoblasts from human embryonic stem cells

Article Abstract:

The article reports a stroma-free induction system for deriving mesenchymal precursors suitable for transplantation of human embryonic stem cells (hESCs) for cell therapy in degenerative diseases. The study reported that the hESCs-derived skeletal myoblasts were viable after transplantation into the tibialis anterior muscle of the Beige mice.

Degeneration (Pathology)

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