Human immunoglobulin therapy for preeclampsia associated with lupus anticoagulant and anticardiolipin antibody

Article Abstract:

The case report is presented of a woman with five previous miscarriages who developed preeclampsia (headache, edema, protein excretion and high blood pressure) at 24 weeks' gestation. In addition to multiple medical problems, the patient had lupus anticoagulant and anticardiolipin antibodies (antiphospholipid antibodies), an immune disorder associated with miscarriage. Treatment with immunoglobulin (Ig) was instituted to reduce the immune response, and bedrest was prescribed. During the pregnancy, several more courses of Ig treatment were necessary. At 32 weeks' gestation, induction of labor was attempted, but fetal distress developed; a male infant was then delivered by cesarean. The infant and mother were ultimately discharged in good health. The use of Ig in pregnancy should only be considered if anticardiolipin and anticoagulant antibodies are present and the fetus is immature. (Consumer Summary produced by Reliance Medical Information, Inc.)

Health aspects, Causes of, Drug therapy, Immunoglobulins, Preeclampsia, Antiphospholipid antibodies, Anticardiolipin antibodies

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Transvaginal versus transabdominal Doppler auscultation of fetal heart activity: a comparative study

Article Abstract:

Transvaginal Doppler ultrasound appears to detect the fetal heart beat earlier than transabdominal ultrasound. A group of 141 women between six and twelve weeks pregnant had both procedures. Vaginal ultrasound examination detected the fetal heart beat in 61% of cases versus 23% of abdominal ultrasound examinations in week 8 of pregnancy. In week 9, vaginal ultrasound detected the heart beat in 88% of pregnancies versus 56% for abdominal ultrasound. Neither technique could accurately determine that there was no fetal heart beat.

Methods, Evaluation, Fetus, Fetal heart rate monitoring, Electronic fetal monitoring, Doppler ultrasonography, Prenatal ultrasonography, Ultrasonics in obstetrics

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