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Lack of effect of induction of hypothermia after acute brain injury

Article Abstract:

Deliberately inducing hypothermia, or low body temperature, in patients with brain injury does not appear to improve their outcome. This was the conclusion of a study of 392 patients in a coma after a head injury who were randomly assigned to hypothermia treatment or no cooling.

Author: Clifton, Guy L., Miller, Emmy R., Choi, Sung C., Levin, Harvey S., McCauley, Stephen, Smith, Kenneth R., Jr., Muizelaar, J. Paul, Wagner, Franklin C., Jr., Marion, Donald W., Luerssen, Thomas G., Chesnut, Randall M., Schwartz, Michael
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
Coma, Coma (Medicine)

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Hypothermia for traumatic brain injury -- a good idea proved ineffective

Article Abstract:

Hypothermia may be effective for patients with brain injury if it is begun within 90 minutes after the injury. Hypothermia is a lower than normal body temperature that is often deliberately induced for therapeutic purposes. A study published in 2001 showed it had no benefit in brain injured patients but the patients did not reach the target temperature until 8 hours after the injury.

Author: Narayan, Raj K.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
Editorial

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Treatment of traumatic brain injury with moderate hypothermia

Article Abstract:

Cooling patients with brain injuries for about 24 hours appears to improve their prognosis but only if their prognosis was initially good. Researchers randomly assigned 82 patients with brain injuries to 24 hours of hypothermia or 24 hours of normal temperatures. After one year, the hypothermia treatment reduced the chance of a bad outcome by 50% overall. However, this was only true in those with Glasgow coma scores of 5 to 7, which is an indication of mild to moderate injury. At one year, these patients' chance of a bad outcome was reduced 70%.

Author: Kelsey, Sheryl F., Marion, Donald W., Kochanek, Patrick M., DeKosky, Steven T., Wisniewski, Stephen R., Penrod, Louis E., Obrist, Walter D., Palmer, Alan M.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1997
Evaluation, Injuries, Brain, Fever, Hyperthermia, Brain injuries

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Subjects list: Health aspects, Care and treatment, Head injuries, Hypothermia, Induced, Induced hypothermia
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