IgG3 cryoglobulins in autoimmune MRL-lpr/lpr mice: immunopathogenesis, therapeutic approaches and relevance to similar human diseases

Article Abstract:

Immunoglobulin G3 (IgG3) cryoglobulins may play an important role in the development and progression of different autoimmune diseases. Cryoglobulins are different types of immunoglobulins that precipitate out of blood or solution at temperatures below 37 degrees Centigrade. MRL-lpr/lpr mice are a strain of mice that spontaneously develop an autoimmune disease similar to lupus erythematosus or rheumatoid arthritis. Blood levels of cryoglobulins are usually high in this strain of mice. A large proportion of the cryoglobulins from these mice were from the IgG3 subclass. Cryoglobulins with rheumatoid factor activity can cause the development of a vascular skin rash and inflammation of the kidneys. A similar type of activity may contribute to the development of kidney disease in human suffering from lupus erythematosus.

Development and progression, Autoimmune diseases, Immunoglobulin G

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Cryoglobulins are not essential

Article Abstract:

The diagnosis of essential cryoglobulinemia may be inaccurate in many patients. Cryoglobulins are dissolved blood proteins which solidify and fall out of solution when the temperature drops below body temperature. Cryoglobulin precipitates can accumulate in the skin, kidneys, and other organs and cause significant damage. Essential cryoglobulinemia describes the presence of cryoglobulins in the blood, with no apparent cause. However, a significant number of these patients may have chronic hepatitis C virus infection or other conditions. Cryoglobulinemia in isolation is rare.

Methods, Diagnosis, Diagnosis, Laboratory, Laboratory diagnosis

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Anticardiolipin autoantibodies in serum samples and cryoglobulins of patients with chronic hepatitis C infection

Article Abstract:

Many patients with hepatitis C have antibodies against cardiolipin. In a study of 48 hepatitis C patients, 44% had anti-cardiolipin antibodies. However, none had any physical symptoms from the autoantibodies. Cardiolipin is a naturally occurring substance in the body.

Health aspects, Autoantibodies, Anticardiolipin antibodies

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