Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

Article Abstract:

In healthy individuals, declining thymic output affects T cell receptor excision circles (TRECs) in conjunction with naive T-cell division whereas in HIV-1 infected individuals, declining TRECs are correlated with the changes in peripheral T-cell division, which does not involve thymic impairment. This suggests a relationship between immune activation and TREC content.

Netherlands, Ethiopia, Statistical Data Included, Analysis, T cell antigen receptors, Cell division, Thymus, Thymus gland, Immunological research, Immunologic research

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The dominant source of CD4+ and CD8+ T-cell activation in HIV infection is antigenic stimulation

Article Abstract:

The persistence of HIV antigens may explain why T cell activation persists in HIV patients even when they take AIDS drugs. This was the conclusion of a study of 47 HIV patients before and after they began drug treatment.

HIV (Viruses), HIV, Viral proteins

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HIV-1 subtype C Gag-specific T-cell responses in relation to human leukocyte antigens in a diverse population of HIV-infected Ethiopians

Article Abstract:

HIV-1 subtype C T-cell responses measured in a diverse population of infected Ethiopian subjects using synthetic Gag peptides is presented as it is a necessary requisite in the development of HIV vaccine.

Science & research, Research, Drug therapy, Clinical report

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