Hypoxia of the renal medulla - its implications for disease

Article Abstract:

Research on renal medullary hypoxia has shed light on ways to protect patients from kidney damage. The renal medulla is the part of the kidney that concentrates urine to conserve body water. However, this reduces the oxygen content of the medulla, a condition called hypoxia. The body has many ways of minimizing the damage to the medulla. The medulla has receptors for many chemicals that relax blood vessels in the kidney, which increases oxygen content. However, many drugs can increase medullary hypoxia by reducing blood flow or increasing the transport of ions in the kidney tubules. These drugs include some antibiotics, non-steroidal anti-inflammatory drugs and contrast dyes used in imaging procedures. Medullary hypoxia can not be detected, but it can be minimized by infusing a salt solution into hospitalized patients who are receiving these chemicals.

Physiological aspects, Kidneys, Hypoxia, Anoxia, Kidney

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Anaritide in acute tubular necrosis

Article Abstract:

Anaritide does not appear to improve kidney function in people with acute tubular necrosis except in those whose urine output has dropped. Acute tubular necrosis is a type of kidney disease. Researchers randomly assigned 504 patients with acute tubular necrosis to receive an intravenous infusion of placebo or anaritide, which is a synthetic form of atrial natriuretic peptide. Overall, anaritide did not improve kidney function significantly better than placebo. However, it did improve kidney function in patients with decreased urine production.

Health aspects, Drug therapy, Acute renal failure, Acute kidney failure, Natriuretic peptides

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