Increased frequency of detection of human papillomavirus deoxyribonucleic acid in exfoliated cervical cells during pregnancy

Article Abstract:

Some human papillomavirus (HPV) strains have been associated with pre-cancer and cancer of the cervix. Methods of detection use isolating sections of DNA that are specific to HPV to confirm the presence of the virus. (Viruses alter cell replication by altering the genetic code in DNA.) HPV infections are more readily detected in patients with altered immune systems. These infections are also more frequently found during pregnancy, less often after delivery. The relationship between the varied hormone levels found before and after pregnancy and HPV prevalence is unknown. The presence of HPV infections in cells scraped off the cervix (exfoliated) was determined in 110 women during pregnancy and after delivery; fluctuations in detectability were noted. First trimester pregnancies had a 20.9 percent detection rate and third trimester rates increased to 46 percent. The results during the post-delivery period decreased to 17.5 percent. Fluctuations, therefore, do occur, and the hormonal changes found during and after pregnancy may be responsible and should therefore be investigated. True prevalence of HPV infections may be higher than described in some non- pregnant women as well.

Measurement, Causes of, Risk factors, Physiological aspects, Development and progression, DNA, Virus diseases, Papillomavirus infections, Warts

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Human papillomavirus deoxyribonucleic acid detection in mildly or moderately dysplastic smears: a possible method for selecting patients for colposcopy

Article Abstract:

Human papillomavirus (HPV) screening tests appear to be simple and moderately useful secondary tests for determining which patients do not need a microscopic cervical examination called a colposcopy to rule out cervical cancer. One hundred ninety patients with questionable Pap smear tests were given HPV tests. These test results were compared with colposcopy results. One-third of the patients with negative colposcopy results had negative HPV test results. A small percentage of the patients with positive colposcopy results had negative HPV tests.

Papillomaviruses, Papillomavirus, Identification and classification, Pap test, Colposcopy

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Microsatellite alterations in exfoliated cervical epithelia deoxyribonucleic acid as a marker for high-grade dysplasia

Article Abstract:

Analyzing cervical tissue samples for DNA changes appears to be accurate in detecting precancerous changes. In a study of 498 women with an abnormal Pap smear, this technique was more accurate than human papillomavirus testing.

Medical examination, Vaginal smears

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