Cerebrospinal fluid mononuclear cell counts influence CSF HIV-1 RNA levels

Article Abstract:

HIV in the cerebrospinal fluid (CSF) of HIV patients appears to be produced mostly by infected mononuclear cells. These cells are a normal component of blood. Researchers analyzed HIV levels in CSF as well as the number of mononuclear cells in the fluid. Patients with many mononuclear cells in their CSF were more likely to have evidence of HIV in the fluid. CSF HIV levels were also higher in patients with higher mononuclear cell counts. Patients with opportunistic infections of the central nervous system had higher CSF HIV levels.

Analysis, Measurement, HIV (Viruses), HIV, Monocytes, Cerebrospinal fluid

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Enhancement of natural killer and antibody-dependent cytolytic activities of the peripheral blood mononuclear cells of HIV-infected patients by recombinant IL-15

Article Abstract:

The authors researched possible methods of enhancing natural killer cells, which kill virus-infected cells, but which are impaired in HIV-infected people. They found that a recombinant form of interleuken-15 (IL-15) may be better than IL-2 at improving the natural killer cells' ability to do their job.

Health aspects, Interleukins, Killer cells

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