Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea

Article Abstract:

Researchers have shown that people with rosacea express abnormally high levels of cathelicidin in their facial skin and that the proteolytically processed forms of cathelicidin peptides found in rosacea are different from those present in normal individuals. The analysis has confirmed the role of cathelicidin in skin inflammatory responses and has shown that an exacerbated innate immune response can reproduce elements of rosacea.

Science & research, Health aspects, Causes of, Acne rosacea, Proteolysis, Clinical report

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The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection

Article Abstract:

The production and function of the cathelicidin antimicrobial peptides LL-37, its precursor hCAP-18 and its ortholog CRAMP in epithelial cells of human and mouse urinary tract respectively is described. Bacterial contact with epithelial cells resulted in rapid production and secretion of the respective peptides, and in humans LL-37/hCAP-18 was released into urine.

Care and treatment, United States, Anti-infective agents, Urinary tract infections

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Downregulation of bacterial peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator

Article Abstract:

One characteristic of Shigella spp. infection is reduction or turning off of antibacterial peptide expression. This downregulation suggests Shigella plasmid DNA is one mediator in the virulence parameter.

Sweden, Bangladesh, Genetic aspects, DNA, Bacterial genetics

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