Increased tumor necrosis factor-alpha production after lipopolysaccharide stimulation of whole blood in patients with previous preterm delivery complicated by intra-amniotic infection or inflammation

Article Abstract:

Women with a history of premature birth may have a pro-inflammatory immune response. This was the conclusion of researchers who found that women with a previous history of premature birth and uterine infection or inflammation had higher blood levels of tumor necrosis factor alpha. Tumor necrosis factor alpha is a pro-inflammatory substance produced by the immune system.

Health aspects, Risk factors, Tumor necrosis factor

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Adverse outcomes after preterm labor are associated with tumor necrosis factor-alpha polymorphism -863, but not -308, in mother-infant pairs

Article Abstract:

Two single-base polymorphisms of tumor necrosis at positions -863 and -308 were tested for association with adverse outcomes in mother-infant pairs with preterm labor. In women with preterm labor before 34 weeks' gestation, maternal homozygous carriage of the -863 polymorphism could be associated with preterm delivery.

United States, Science & research, Research, Causes of, Genetic polymorphisms, Labor, Complicated, Labor complications, Labour complications

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Intrauterine infection and preterm delivery: evidence for activation of the fetal hypothalamic-pituitary-adrenal axis

Article Abstract:

Intrauterine infection appears to be stressful on the fetus, according to a study of 33 pregnant women. In the 11 with an intrauterine infection, the fetus produced greater amounts of adrenal gland hormones.

Infection, Physiological aspects, Uterus, Hypothalamic-pituitary-adrenal axis

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