Inflammatory bowel disease genetics: Nod2

Article Abstract:

The inflammatory bowel diseases (IBD) are constituted of two major subphenotypes, that is Crohn's disease (CD) and ulcerative colitis (UC). Lately, the association of Nod2 (CARD15) polymorphisms with CD was established, and taken together, the Nod2 association to CD provides an illustrative model of the role of the single gene variants in disease pathogenesis for common, complex multigene disorders. General features of IBD genetics with particular focus on the role of Nod2 in CD, are reviewed.

United States, Genetic aspects, Genetic polymorphisms, Ulcerative colitis, Linkage (Genetics), Clinical report

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Inducing intestinal growth

Article Abstract:

New approaches to the treatment of intestinal and epithelium-related disorders are described. Scientists discovered that R-spondin1, a newly identified human protein, activates beta-catenin signaling and dramatically increases the proliferation and growth of the small and large intestines in mice.

New England States, Care and treatment, Growth, Intestines, Cell proliferation, New England, Gastrointestinal diseases, Colorectal diseases, Intestinal diseases, Company growth

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Bugging of the intestinal mucosa

Article Abstract:

The Escherichia coli bacteria present in the intestines of patients with Crohn's disease causing an inflammatory bowel disease is presented.

Complications and side effects, Inflammatory bowel diseases, Intestinal mucosa

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