Influence of indomethacin on extracellular calcium homeostasis

Article Abstract:

Rheumatoid arthritis (RA) is a disorder characterized by inflammation of the joints, swelling, stiffness, overgrowth of cartilage, and pain. RA is associated with a general loss of bone, but this may possibly be due to the long-term use of non-steroidal anti-inflammatory drugs (NSAIDs). These agents increase gastrointestinal permeability, the ability of substances to pass through the membranes of the stomach and intestine, and may thereby affect calcium absorption. NSAIDs also affect the rate at which blood is filtered through the kidneys and the kidney excretion of calcium. The processes of formation of bone by osteoblasts and the resorption or dissolution of bone by osteoclasts may be altered by these anti-inflammatory agents. Calcium homeostasis, or metabolism, was examined in eight healthy subjects who were given the non-steroidal anti-inflammatory agent indomethacin daily for eight days. Blood levels of calcium, phosphorus, and various factors that control calcium metabolism, including parathyroid hormone, 25-hydroxyvitamin D3, and 1,25-dihydroxyvitamin D3, did not change, although calcium excretion was decreased. This reduction in the elimination of calcium probably resulted from the kidney retention of calcium. The effect of kidney retention of calcium on bone mass is not known. (Consumer Summary produced by Reliance Medical Information, Inc.)

Nonsteroidal anti-inflammatory drugs, Nonsteroidal anti-inflammatory agents, Calcium metabolism, Indomethacin

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Self report functional disability scores and the use of devices: two distinct aspects of physical function in rheumatoid arthritis

Article Abstract:

The long-term effect of rheumatoid arthritis (RA) on a patient's daily life should be predicted from both self reported scores of functional disability and use of medical devices. RA is an inflammatory disease that affects the joints. A study compared different measurements of disability in 197 RA patients. Ninety-seven patients had had RA for less than a year, and 100 patients had had RA for a year or more. All the patients completed the Dutch version of the Health Assessment Questionnaire Disability Index. The functional disability scores reflected the level of inflammation and patients' sense of psychological well being. The use of medical devices reflected the length of disease duration regardless of the current level of disease activity.

Usage, Disability evaluation, Medical equipment

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Aggressive treatment in early rheumatoid arthritis: a randomised controlled trial

Article Abstract:

Methotrexate or sulfasalazine appear to be the most effective treatments for early rheumatoid arthritis. In a study of 313 patients, intramuscular gold was also effective but was too toxic.

Drug therapy

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