Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator

Article Abstract:

The blood anion nitrite contribute to hypoxic vasodilation through a heme-based, nitric oxide (NO) and the biochemical reaction could be harnessed for the treatment of neonatal pulmonary hypertension. An experiment conducted by inhaling sodium nitrite by aerosol to newborn lambs with hypoxic and normoxic hypertension is presented. The results revealed that nitrite is a simple and inexpensive potential therapy for neonatal pulmonary hypertension.

Science & research, Health aspects, Research, Pulmonary hypertension, Nitrites

---

Nitric oxide's reactions with hemoglobin: a view through the SNO-storm

Article Abstract:

This article evaluates the role of S-nitroso-hemoglobin in the regulation of basal blood flow and tissue oxygenation through allosteric binding and delivery of nitric oxide and oxygen. Research shows that this hypothesis is not tenable but an alternative pathway of nitric oxide scavenging by hemoglobin and nitric oxide production by endothelial cells may be determining nitric oxide bioavailability.

Hemoglobin, Hemoglobins, Oxygen transport, Metabolic regulation, Blood circulation

---

Hemoglobin and the paracrine and endocrine functions of nitric oxide

Article Abstract:

Nitric oxide is produced by blood vessels and most researchers believe it only acts on surrounding tissues to relax the blood vessel. However, there is some evidence that it can be transported in the blood to other parts of the body. This would make it act more like a hormone. It could also be used as a drug to treat some cardiovascular diseases.

Similar abstracts:

• Abstracts: Tuberculin and anergy testing in HIV-seropositive and HIV-seronegative persons. Bacterial pneumonia in persons infected with the human immunodeficiency virus
• Abstracts: A 58-year-old man with progressive hypotension and respiratory failure after treatment for apparent pulmonary tuberculosis
• Abstracts: Dealing with disclosure. A prion protein epitope selective for the pathologically misfolded conformation. Building the translational highway: toward new partnerships between academia and the private sector

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.