Indomethacin blocks interleukin 1beta-induced myometrial contractions in pregnant rhesus monkeys

Article Abstract:

Indomethacin prevents uterine contractions in the presence of the inflammatory immune system protein interleukin 1beta. Infection can stimulate the production of interleukin 1beta, and this supports the theory that infection in the uterus can cause premature birth.

Indomethacin

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Dexamethasone or interleukin-10 blocks interleukin-1beta-induced uterine contractions in pregnant rhesus monkeys

Article Abstract:

Dexamethasone and interleukin-10 could be used to stop premature labor in pregnant women with an intrauterine infection, according to a study in rhesus monkeys. Studies have shown that intrauterine infections stimulate the production of interleukin-1beta, which causes inflammation. Dexamethasone and interleukin-10 inhibit the production of interleukin-1beta.

Biological Product (except Diagnostic) Manufacturing, Biological products exc. diagnostic, Interleukin, Evaluation, Prevention, Interleukins, Premature labor, Dexamethasone, Premature labour

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Inhibition and augmentation of progesterone production during pregnancy: effects on parturition in rhesus monkeys

Article Abstract:

Reductions in progesterone levels may lead to preterm labor and delivery, but high levels of progesterone at term does not prevent delivery. Researchers administered a progesterone inhibitor known as epostane, epostane plus progesterone, or progesterone alone to 11 rhesus monkeys in the last trimester of pregnancy. Epostane administration was associated with a 75% progesterone reduction, leading to cervical ripening and vaginal delivery within 48 hours. Administration of progesterone did not prevent delivery at term, perhaps because it could not reach key intrauterine tissues.

Premature birth, Progesterone, Progesterone antagonists

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• Abstracts: Induction of premature labor and delivery by allergic reaction and prevention by histamine H(sub 1) receptor antagonist
• Abstracts: An appraisal of treatment guidelines for antepartum community-acquired pneumonia. Acute pancreatitis in pregnancy

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