Inhibition of HIV replication by dominant negative militants of Sam68, a functional homolog of HIV-1 Rev

Article Abstract:

A cellular nuclear protein, Sam68, Src-associated protein in mitosis, a functional homolog of HIV-1 Rev, has been found to interact specifically with Rev response element (RRE) and to be able to partially substitute for and synergize with Rev in virus replication and RRE-mediated gene expression. Rev, encoded by complex retroviruses, is an essential regulatory protein which mediates the nuclear export of unspliced or incompletely spliced viral RNA.

Physiological aspects, Nucleoproteins, Viruses, Messenger RNA, Proteomics

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Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1

Article Abstract:

A cytoplasmically localized fragment of INI1 (S6; aa 183-294) containing the minimal integrase-interaction domain potently inhibiting HIV-1 particle production and replication is reported. Results indicated that INI1 is required for late events in the viral life cycle, and that ectopic expression of S6 inhibits HIV-1 replication in a transdominant manner provides a new strategy to control HIV-1 replication.

Care and treatment, Mutation (Biology), Mutation, Cytoplasmic filaments

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Redistricting the retroviral restriction factors

Article Abstract:

Several studies revealed that cytoplasmic protein TRIM5alpha is a broadly active inhibitor for the growth of HIV in rhesus monkey cells. The antiviral activities of these proteins are analyzed and the results are discussed.

Risk factors, Proteins

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