Insignificant transfer of glyburide occurs across the human placenta

Article Abstract:

This study was undertaken to investigate whether glyburide, a commonly used drug to enhance glycemic (blood glucose) control, crosses the placental barrier, which might exert detrimental effects on the fetus. Pregnant women with diabetes should maintain tight glycemic control, but insulin (the drug most commonly prescribed for this purpose) may cross the placenta as part of a molecular complex, which can cause fetal complications. The passage of glyburide across the placental barrier was studied using placentas from uncomplicated term pregnancies. Results showed that essentially no transfer of the drug took place, as measured by techniques that assess protein binding, lipid solubility, or molecular weight. Transfer was not seen even when glyburide was used at high concentrations. Glyburide and other oral hypoglycemic agents (drugs to lower blood levels of glucose) besides insulin, are presently prohibited in the US although they are used in other countries. This restriction has been made in part because of fears that the drugs could affect the fetus, based on the assumption that they do cross the placenta. Results from this study suggest that glyburide is potentially useful for controlling gestational diabetes, and further investigation is recommended. (Consumer Summary produced by Reliance Medical Information, Inc.)

Health aspects, Drug therapy, Hypoglycemic agents

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The association between preeclampsia and the severity of gestational diabetes: The impact of glycemic control

Article Abstract:

The relationship between rate of preeclampsia and the severity of gestational diabetes mellitus (GDM), and whether optimizing glycemic control can decrease it, is determined in a study. Results show that the rate of preeclampsia is influenced by the severity of GDM and pre-pregnancy body mass index (BMI), and that optimizing glucose control during pregnancy may decrease the rate of preeclampsia, even in those with a greater severity of GDM.

Science & research, Research, Preeclampsia, Body mass index

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Insulin and glyburide therapy: Dosage, severity level of gestational diabetes, and pregnancy outcome

Article Abstract:

The association between glyburide dose, degree of severity in gestational diabetes mellitus (GDM), level of glycemic control, and pregnancy outcome in insulin- and glyburide-treated patients is investigated. Glyburide and insulin are equally efficient for treatment of GDM in all levels of disease severity.

Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Gynecological R&D, Patient outcomes, Pregnancy, Complications of, Pregnancy complications, Glibenclamide, Glyburide, Gynecological research

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