Insomnia in prion diseases: sporadic and familial

Article Abstract:

A 1999 report adds to the evidence that there is a sporadic form of fatal familial insomnia. Fatal familial insomnia is a type of disease called a prion disease. This is because it is associated with an abnormal form of the normal prion protein, which occurs in the brain. The report documents a patient who developed fatal familial insomnia but who had a normal prion gene. Fatal familial insomnia is usually caused by a gene mutation. The fact that the patient had a normal gene indicates that his disease was not passed down from his parents, but occurred spontaneously.

Health aspects, Editorial, Case studies, Spongiform encephalopathy, Prion diseases

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Celecoxib for the prevention of sporadic colorectal adenomas

Article Abstract:

Celecoxib drug is prescribed to patients who had colonic adenomas removed before study entry so as to verify whether the cyclooxygenase-2 (COX-2) inhibitor celecoxib, originally developed for the treatment of pain and inflammation, also prevents sporadic colorectal adenomas. Findings indicate that celecoxib is effective in preventing colorectal adenomas, but its routine use is ruled out due to the possibility of serious cardiovascular events.

Drug therapy, COX-2 inhibitors, Dosage and administration, Adenoma, Celecoxib, Drug overview

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Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob disease

Article Abstract:

The abnormal protein that causes Creutzfeldt-Jakob disease (CJD) can occur in other parts of the body besides the brain, according to a study of 36 patients who died of CJD. The researchers tested autopsy samples for the presence of the prion protein and found that one-third of the patients had prion protein in other parts of the body, including the spleen and muscles. CJD belongs to the same group of diseases as mad cow disease.

Physiological aspects, Creutzfeldt-Jakob disease

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