Integration of endoplasmic reticulum signaling in health and disease

Article Abstract:

Integration of endoplasmic reticulum (ER) signaling in health/disease is discussed. Change in the ER processing of cargo molecules by pathogens or inadequacies in cargo handling by the ER mechanisms in a range of diseases from cystic fibrosis to hemochromatosis and neuropathies such as Alzheimer disease shows a surprising role of the ER in cell fate control. Topics include chaperones in assisted folding in the ER and cellular control of ligands regulating ER export.

Physiological aspects, Endoplasmic reticulum, Cytochemistry, Protein folding

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BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect

Article Abstract:

It is believed that retinoids cause extensive apoptosis of medulloblastoma cells. Bone morphogenetic protein-2 (BMP-2) was identified as a candidate mediator of retinoid activity, which induced medulloblastoma cell apoptosis, whereas the BMP-2 antagonist noggin blocked both retinoid and BMP-2-induced apoptosis.

Science & research, Influence, Retinoids, Apoptosis

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The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells

Article Abstract:

Research presented concerns the mechanism responsible for medulloblastoma tumorigenesis. Topics addressed include neuronal differentiation, and the use of neuronal repressor element 1 silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) in therapy interventions.

Statistical Data Included, Brain tumors

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