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Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A

Article Abstract:

Chimeras of P-selectin and immunoglobulin induced formation of procoagulant microparticles in human blood through P-selectin glycoprotein ligand-1. It is believed that P-sel-lg treatment could become a new approach to sustained control of bleeding in hemophilia.

Author: Camphausen, Raymond T., Wagner, Denisa D., Cambien, Beatrice, McEver, Rodger P., Hrachovinova, Ingrid, Hafezi-Moghadam, Ali Kappelmayer, Janos, Widom, Angela, Lijun Xia, Kazazian, Haig H. Jr., Schaub, Robert G.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Science & research, Research, Hemophilia, Immunoglobulins

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Nucleotides and cd39: principal modulatory players in hemostasis and thrombosis

Article Abstract:

The discovery of the cd39 protein in endothelial cells shows that ATP, ADP, and AMP help regulate blood clotting. cd39 hydrolyzes nucleotides, converting ATP/ADP to AMP. ATP/ADP promote blood clotting whereas AMP inhibits blood clotting.

Author: Zimmerman, Herbert
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999

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Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation

Article Abstract:

The cd39/ATP diphosphohydrolase regulates hemostasis and thrombosis by converting ATP/ADP to AMP. The enzyme is located in endothelial cells and other cells.

Author: Rosenberg, Robert D., Frenette, Paul S., Wagner, Denisa D., Csizmadia, Eva, Beeler, David L., Rayburn, Helen, Robson, Simon C., Enjyoji, Keiichi, Sevigny, Jean, Lin, Yuan, Christie, Patricia D., Esch, Jan Schulte am, II, Imai, Masato, Edelberg, Jay M., Lech, Miroslaw
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999

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Subjects list: Hemostasis, Physiological aspects, Nucleotides, Blood clotting, Blood coagulation
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