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Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection

Article Abstract:

A strategy is described for fetal chromosomal dosage assessment that can be performed noninvasively through analysis of placental expressed mRNA in maternal plasma. The noninvasive prenatal diagnosis of fetal trisomy 21 can be achieved by determining the ratio between alleles of a single-nucleotide polymorphism (SNP) in PLAC4 mRNA, which is transcribed from chromosome 21 and expressed by the placenta, in maternal plasma.

Author: Nicolaides, Kypros H., Cantor, Charles R., Tse N. Leung, Lo, Y.M. Dennis, Tsui, Nancy B.Y., Chiu, Rossa W.K., Tze K. Lau, Heung, Macy M.S., Gerovassili, Ageliki, Yongjie Jin, Chunming Ding
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
United Kingdom, China, Placenta, Messenger RNA, Chromosomes

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Role of deficient type III interferon-lamda production in asthma exacerbations

Article Abstract:

Studies were conducted to show deficient induction of interferon-lamda by rhinovirus-induced asthma exacerbation and virus load in experimentally infected human volunteers. The results identified previously unknown mechanisms of susceptibility to infection in asthma and suggested new approaches to prevention and treatment of asthma exacerbations.

Author: Edwards, Michael R., Holgate, Stephen T., Contoli, Marco, Message, Simon D., Laza-Stanca, Vasile, Wark, Peter A.B., Bartlett, Nathan W., Kebadze, Tatiana, Mallia, Patrick, Stanciu, Luminita A., Parker, Hayley L., Slater, Louise, Lewis-Antes, Anita, Kon, Onn M., Davies, Donna E., Kotenko, Sergei V., Papi, Alberto, Johnston, Sebastian L.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
United States, Care and treatment, Prevention, Genetic aspects, Asthma, Interferon inducers

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Subjects list: Research
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