Involvement of simultaneous multiple transcription factor expression, including cAMP responsive element binding protein and OCT-1, for synovial cell outgrowth in patients with rheumatoid arthritis

Article Abstract:

Simultaneous expression of several gene transcription factors may be associated with the inflammatory and destructive changes of rheumatoid arthritis. Rheumatoid arthritis is an autoimmune inflammatory joint disease. Researchers used immunohistochemistry to analyse synovial tissue from patients with rheumatoid arthritis and found that gene transcription factors were simultaneously expressed in overgrown joint tissues. Simultaneous expression of multiple genes related to tissue development may underlie the progressive joint disease.

Genetic regulation, Genetic transcription, Transcription (Genetics)

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Antisense oligonucleotides targeting c-fos mRNA inhibit rheumatoid synovial fibroblast proliferation

Article Abstract:

Antisense oligonucleotides may inhibit genetic activity which promotes the overgrowth of synovial tissue in rheumatoid arthritis. Researchers tested this form of gene therapy in samples of synovium from rheumatoid arthritic joints. Specific oligodeoxynucleotides appeared to block expression of a gene thought to be associated with the growth of synovial fibroblast cells. Fibroblast proliferation was inhibited in the genetically transfected tissue. This may form the basis of an effective therapy for rheumatoid arthritis.

Research, Physiological aspects, Gene therapy, Antisense nucleic acids

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Synovial membrane p53 protein immunoreactivity in rheumatoid arthritis patients

Article Abstract:

Levels of the p53 protein are not increased in the synovial membranes of patients with rheumatoid arthritis. This indicates that the normal protein exists in these patients, not the abnormal form. The abnormal form causes cell proliferation and was believed to be involved in the development of rheumatoid arthritis.

Health aspects, Tumor suppressor genes

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