Is noncentral obesity metabolically benign? Implications for prevention from a population survey

Article Abstract:

People who are noncentrally obese may still need to lose weight to lower their risk factors for heart disease. Central obesity occurs when people gain weight mostly in their abdomen and is often detected by a high body mass index (BMI) and a large waist-to-hip ratio (WHR). People who have a high BMI but a low WHR have a condition called noncentral obesity. Canadian researchers took blood samples from 2,339 people in the Manitoba Heart Health Survey and measured total cholesterol, LDL and HDL cholesterol and glucose. Blood pressure measurements were also taken. The participants were classified as nonobese, noncentrally obese or centrally obese. Noncentrally obese men had higher blood pressure and cholesterol measurements than men who were nonobese. In fact, their measurements were similar to those of centrally obese men. Noncentrally obese women differed significantly from centrally obese women except for their diastolic blood pressure.

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The relation of gastroesophageal reflux disease and its treatment to adenocarcinomas of the esophagus and gastric cardia

Article Abstract:

H2 antagonists and anticholinergics do not appear to contribute to adenocarcinomas of the esophagus or gastric cardia. These drugs are commonly used in the treatment of gastroesophageal reflux disease and peptic ulcer. A total of 196 patients with adenocarcinoma and 196 matched controls were studied. Excess risk for adenocarcinoma was seen only in patients with a prior gastroesophageal condition, after adjustments were made for body mass index, smoking, and race. Gastroesophageal conditions included hiatal hernia, esophageal diseases, and swallowing difficulty. The use of H2 antagonists, however, was linked to a four times higher risk for adenocarcinoma among patients who used four or more prescriptions, but the risk was reduced after adjusting for prior gastroesophageal conditions. No risk was associated with use of anticholinergics. In fact, risk decreased with more prescriptions for anticholinergics.

Drug therapy, Adenocarcinoma, Antiulcer agents, Parasympatholytic agents, Parasympatholytics, Antiulcer drugs

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Obesity and estrogen as risk factors for gastroesophageal reflux symptoms

Article Abstract:

Obesity and female sex appear to be risk factors for gastroesophageal reflux, according to a study of 65,363 people. The risk of gastroesophageal reflux was three times greater in severely obese men and six times greater in severely obese women compared to men and women with normal weights. Premenopausal women and postmenopausal women who used estrogen replacement therapy had a greater risk than men. Gastroesophageal reflux occurs when food in the stomach backs up into the esophagus.

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