Ketoconazole to reduce the need for cyclosporine after cardiac transplantation

Article Abstract:

Ketoconazole may reduce the incidence of transplant rejection, infection, and the need for cyclosporine in heart transplant recipients. Following heart transplantation, 23 patients received 200 milligrams/day of ketoconazole with cyclosporine and 20 patients received no ketoconazole with cyclosporine. Ketoconazole reduced the need for cyclosporine by 80% a year after transplantation. The rate of transplant rejection was lower in the ketoconazole group than in the control group, particularly in the first month after transplant. Ketoconazole recipients also had a lower rate of infection and need for cytolytic therapy. Using ketoconazole led to a cost reduction of approximately $5,200 per patient in the first year, and $3,920 per patients in subsequent years. The only observed side effect of ketoconazole was visual flashes, which resolved without stopping therapy in the two patients that experienced them.

Ketoconazole

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Taking heart--Cardiac transplantation: Past, present, and future

Article Abstract:

The initial enthusiasm for the first human-to-human transplantation, performed in South Africa and the US in 1967 and 1968, subsided when it became known that survival rates were usually measured in days or weeks due to an inadequate understanding of the type of postoperative complications one should anticipate. In the 21st century, in the US, a summation of advances in this field has produced an annual cohort of about 2000 new transplant recipients and in future there are likely to be more improvements in the quality and length of life for heart-transplant recipients.

Forecasts, trends, outlooks, New England States, Forecasts and trends, Complications and side effects, Prognosis, Market trend/market analysis, New England

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A controlled trial of exercise rehabilitation after heart transplantation

Article Abstract:

Exercise training can improve heart function in patients who have a heart transplant. Researchers randomly assigned 27 patients who had received a heart transplant in the past two weeks to participate in a structured exercise program at a cardiac rehabilitation clinic or to receive unstructured therapy at home. Patients attending the clinic received training from a physical therapist. Stress tests at one and six months after transplantation showed that the patients attending the clinic had improved heart function compared to those at home.

Exercise therapy, Cardiac patients

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